Hormel Institute and Mayo Clinic Scientists Publish Research Focused on Preventing Inflammation and Pathology Associated with  Sunburn
Dr. Luke Hoeppner

A team of scientists co-led by Luke Hoeppner, Ph.D., Assistant Professor and leader of the Cancer Biology research section at The Hormel Institute, and Stephen Ekker, Ph.D., Professor of Biochemistry and Molecular Biology at Mayo Clinic and Dean of the Mayo Clinic Graduate School of Biomedical Sciences, recently published findings from preclinical studies that could lead to treatments that reduce inflammation and pathology associated with sunburn. The article, “Vascular Endothelial Growth Factor as an Immediate-Early Activator of Ultraviolet-Induced Skin Injury,” was published in Mayo Clinic Proceedings, a premier general medicine journal.

The negative effects of sunburn are relatively common and can range from simple redness to hospital visits and are known to eventually induce inflammation. For example, in the United
States, sunburn leads to 30,000 emergency room visits every year. Repeated sunburns can cause skin cancer. While current treatments relieve the pain and symptoms, those approaches
do not reverse the cumulative effects of sunburn, in part because they only target secondary or tertiary effects of UV exposure. Dr. Hoeppner and his team report on an early molecular cause of sunburn.

“We hope that we can target this molecular cause to reduce the negative consequences of sunburn,” said Dr. Hoeppner. “We discovered a new step in the process of sunburn that occurs
before inflammation, which opens a new post-exposure window to potentially inhibit all of the negative effects of sunburn. We found that targeting a molecule called vascular endothelial
growth factor (VEGF) reduces the subsequent inflammation and pathology associated with skin damage caused by sunburn.”

“The approach we used in this study was designed to explore options for potential topical treatments,” said Dr. Ekker. “We added VEGF inhibitors after initial UV exposure, to model what happens when people are sunburned and also long after exposure. People often do not realize they are getting sunburned until after they start feeling warm or get flushed. We were able to see VEGF signaling activating in human samples and this strongly suggests there are options to develop interventions and prevent these negative effects.”

The authors emphasize that future clinical studies would be needed to determine the possible value of VEGF inhibitors as a topical sunburn treatment in humans.

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