Dr. Bin Liu, Assistant Professor and leader of the Transcription and Gene Regulation lab at The Hormel Institute, today published discoveries in two top journals.
Dr. Liu’s cutting-edge research is based on data and analysis made using the Institute’s Cryo-electron microscope and Dr. Liu’s expert utilization of the technology.
The article “Structural basis of copper-efflux-regulator-dependent transcription activation” was published in ISCIENCE (2021) and the research team led by Dr. Bin Liu included Drs. W. Shi, B. Zhang, Y. Jiang, C. Liu, W. Zhou, M. Chen, Y. Yang, and Y. Hu. ISCIENCE is a new interdisciplinary open-access journal from Cell Press that provides a platform for original research in the life, physical, and earth sciences.
The article “Structural visualization of transcription activated by a multidrug-sensing MerR family regulator,” was published in Nature Communications (2021) and the research team led by Dr. Bin Liu included Drs. W. Shi, B. Zhang, C. Liu, W. Zhou, M. Chen, Y. Yang, and Y. Hu. Nature Communications is an open access journal from Nature Research that publishes high-quality research from all areas of the natural sciences.
Both projects, using cryo-electron microscopy, developed high resolution structures of MerR family regulator (CueR/EcmrR)-dependent transcription complexes and showed how MerR family regulators reshape the suboptimal spacer DNA to enable optimal promoter recognition and initiate transcription.